Cincinnati vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 11 [2026]

Using innovative machine learning and data analysis, we have re-simulated the outcome of Cincinnati vs. Iowa State, forming part of our college football predictions coverage.

Our leading predictive model gives Iowa State a 56.9% chance of beating Cincinnati. Our predicted final score has Iowa State winning 30-28. According to our model, Iowa State (-2.5) has a 52.2% chance of covering the spread, while the over/under total of 58.5 points has a 51.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Cincinnati +2.5 (+106) / Iowa State -2.5 (-108)
• Moneyline: Cincinnati +130, Iowa State -133
• Total: Over/Under 58.5 (+102/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Iowa State -2.5 @ 52¢ via Novig
• Moneyline: Iowa State @ 57¢ via Novig
• Total: Over 58.5 @ 50¢ via Novig

According to our college football best bets, the top play to make on this game is Over 58.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Iowa State and Cincinnati at Jack Trice Stadium is scheduled to begin at 12:00 PM ET.

• Who: Cincinnati vs. Iowa State
• Date: Saturday, November 14, 2026
• Time: 12:00 PM ET/9:00 AM PT
• Venue: Jack Trice Stadium

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Conclusion

We predict Iowa State, with a 56.9% win probability, will likely beat Cincinnati in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.