College football picks today: Week 4 Saturday best bets include Kansas State vs. Cincinnati play [9/26/2026]

Cincinnati +5.5 (-102)

• Edge: 3.7%
• Probability: 54.2%
• Matchup: Kansas State vs. Cincinnati (7:00PM ET)

Our model has identified value on Cincinnati +5.5 at -102 odds. A 54.2% probability produces an edge of 3.7%, making this the strongest play for today's college football slate.

James Madison vs. Old Dominion Over 43.5 points (-110)

• Edge: 3.6%
• Probability: 56%
• Matchup: James Madison vs. Old Dominion (6:00PM ET)

James Madison vs. Old Dominion over 43.5 points carries a 3.6% edge and a probability of 56% at -110 odds, according to our model.

Wisconsin vs. Penn State Over 43.5 points (-115)

• Edge: 3.4%
• Probability: 56.9%
• Matchup: Wisconsin vs. Penn State (5:00PM ET)

Wisconsin vs. Penn State Over 43.5 points at -115 odds shows a 3.4% edge, supported by a 56.9% probability in simulations.

Old Dominion +6.5 (+100)

• Edge: 3.1%
• Probability: 53.1%
• Matchup: James Madison vs. Old Dominion (6:00PM ET)

A 3.1% edge and 53.1% probability makes Old Dominion +6.5 vs. James Madison a value play in the James Madison vs. Old Dominion matchup, per our model.

Jackson State -20.5 (-110)

• Edge: 2.9%
• Probability: 55.3%
• Matchup: Southern University vs. Jackson State (7:00PM ET)

Jackson State -20.5 at -110 presents a 2.9% edge, with simulations resulting in a probability of 55.3%.

Central Michigan +41.5 (-106)

• Edge: 2.6%
• Probability: 54.1%
• Matchup: Central Michigan vs. Miami Florida (6:30PM ET)

Our model finds value on Central Michigan +41.5 at -106, supported by an edge of 2.6%.

Charlotte +9.5 (-106)

• Edge: 2.6%
• Probability: 54%
• Matchup: Louisiana-Lafayette vs. Charlotte (6:30PM ET)

Our model has uncovered value on Charlotte +9.5 at -106. A 54% probability produces a 2.6% edge, making this a strong play for today's college football action.

Cincinnati ML (+195)

• Edge: 2.5%
• Probability: 36.4%
• Matchup: Kansas State vs. Cincinnati (7:00PM ET)

A 2.5% edge on a 36.4% probability makes Cincinnati to win at +195a solid value play in today's Kansas State vs. Cincinnati matchup.

Murray State +17.5 (-112)

• Edge: 2.2%
• Probability: 55%
• Matchup: Southern Illinois vs. Murray State (7:00PM ET)

Our model projects value on Murray State +17.5 at -112. A 55% probability produces a 2.2% edge, making Murray State the favorable side in today's matchup.

NCAAF best bets summary: Saturday, 9/26/2026

As of 4:37PM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Nebraska vs. Michigan State (5:00PM ET, Saturday)
• Wisconsin vs. Penn State (5:00PM ET, Saturday)
• South Florida vs. Bowling Green (5:00PM ET, Saturday)
• Illinois State vs. Northern Iowa (5:00PM ET, Saturday)
• James Madison vs. Old Dominion (6:00PM ET, Saturday)
• Delaware vs. Virginia (6:00PM ET, Saturday)
• Incarnate Word vs. Texas State (6:00PM ET, Saturday)
• Long Island University vs. Florida International (6:00PM ET, Saturday)
• Towson vs. Delaware State (6:00PM ET, Saturday)
• Campbell vs. Hampton (6:00PM ET, Saturday)

College football offer for Week 4

Make the most of the picks in this article—including Cincinnati +5.5—with the Underdog Fantasy offer below:

Conclusion

Our college football best bets are locked and loaded for September 26, 2026, featuring plays such as Cincinnati +5.5 vs. Kansas State and over 43.5 points in the James Madison vs. Old Dominion matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are based on current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.