Illinois State vs. Northern Iowa prediction favors Illinois State to win in college football Week 4 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Illinois State vs. Northern Iowa, forming part of our college football predictions coverage.

Our leading predictive model currently gives Illinois State an 89.4% chance of beating Northern Iowa. Our predicted final score has Illinois State winning 36-19. According to our model, Northern Iowa (+18.5) has a 53.1% chance of covering the spread, while the 55.5-point over/under has a 51.6% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Illinois State -18.5 (-107) / Northern Iowa +18.5 (-115)
• Moneyline: Illinois State -1040, Northern Iowa +650
• Total: Over/Under 55.5 (-115/-115)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Northern Iowa +18.5 @ -115 via bet365
• Moneyline: Illinois State @ -1040 via DraftKings
• Total: Over 55.5 @ -115 via bet365

According to our college football best bets, the top play to make on this game is Northern Iowa +18.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Northern Iowa and Illinois State at UNI-Dome is scheduled to commence at 5:00 PM ET.

• Who: Illinois State vs. Northern Iowa
• Date: Saturday, September 26, 2026
• Time: 5:00 PM ET/2:00PM PT
• Venue: UNI-Dome

College football Week 4 promos

Make the most of Dimers' Illinois State vs. Northern Iowa predictions by exploring the Underdog Fantasy offer below:

Conclusion

We predict Illinois State, with an 89.4% win probability, will likely beat Northern Iowa in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.