Iowa State vs. BYU prediction favors Brigham Young to win in college football Week 6 [2026]

Using powerful machine learning and data, we have re-simulated the result of Iowa State vs. BYU, forming part of our college football predictions coverage.

Our independent predictive model currently gives Brigham Young an 81.4% chance of defeating Iowa State. Our predicted final score has Brigham Young winning 29-17. According to our model, Brigham Young (-10.5) has a 53.3% chance of covering the spread, while the 46.5-point over/under has a 52.6% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Iowa State +10.5 (-112) / BYU -10.5 (+100)
• Moneyline: Iowa State +330, BYU -400
• Total: Over/Under 46.5 (-106/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Brigham Young -10.5 @ +100 via FanDuel
• Moneyline: Brigham Young @ -400 via Caesars
• Total: Over 46.5 @ -106 via bet365

According to our college football best bets, the top play to make on this game is Brigham Young -10.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football game between BYU and Iowa State at LaVell Edwards Stadium is scheduled to begin at 10:15 PM ET.

• Who: Iowa State vs. Brigham Young
• Date: Friday, October 9, 2026
• Time: 10:15 PM ET/7:15PM PT
• Venue: LaVell Edwards Stadium

College football Week 6 promos

Make the most of Dimers' Iowa State vs. Brigham Young predictions by exploring the Bet365 Sportsbook offer below:

Plus, check out the latest details on the current offer from Kalshi.

Conclusion

We predict Brigham Young, with an 81.4% win probability, will likely beat Iowa State in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.