Southeast Missouri State vs. Charleston Southern prediction: Why Southeast Missouri State is favored to win in college football Week 11 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Southeast Missouri State vs. Charleston Southern, forming part of our college football predictions coverage.

Our independent predictive model currently gives Southeast Missouri State a 58.6% chance of beating Charleston Southern. Our predicted final score has Southeast Missouri State winning 23-20. According to our model, Southeast Missouri State (-1.5) has a 56.1% chance of covering the spread, while the over/under total of 42.5 points has a 54.7% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Southeast Missouri State -1.5 (-115) / Charleston Southern +1.5 (-106)
• Moneyline: Southeast Missouri State -132, Charleston Southern +135
• Total: Over/Under 42.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southeast Missouri State -1.5 @ -115 via BetRivers
• Moneyline: Southeast Missouri State @ -132 via BetRivers
• Total: Over 42.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Southeast Missouri State -1.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Charleston Southern and Southeast Missouri State at Buccaneer Field is scheduled to begin at 2:00 PM ET.

• Who: Southeast Missouri State vs. Charleston Southern
• Date: Saturday, November 14, 2026
• Time: 2:00 PM ET/11:00 AM PT
• Venue: Buccaneer Field

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Conclusion

We predict Southeast Missouri State, with a 58.6% win probability, will likely beat Charleston Southern in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.