Southern Miss vs. Louisiana Tech prediction favors Louisiana Tech to win in college football Week 11 [2026]

Using powerful machine learning and data, we have re-simulated the result of Southern Miss vs. Louisiana Tech, forming part of our college football predictions coverage.

Our leading predictive model gives Louisiana Tech an 89.6% chance of defeating Southern Miss. Our predicted final score has Louisiana Tech winning 36-19. According to our model, Louisiana Tech (-17.5) has a 50.5% chance of covering the spread, while the 55.5-point over/under has a 51.0% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Southern Miss +17.5 (-104) / Louisiana Tech -17.5 (+102)
• Moneyline: Southern Miss +733, Louisiana Tech -770
• Total: Over/Under 55.5 (-106/+104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Louisiana Tech -17.5 @ 50¢ via Novig
• Moneyline: Louisiana Tech @ 89¢ via Novig
• Total: Under 55.5 @ 49¢ via Novig

According to our college football best bets, the top play to make on this game is Louisiana Tech to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Louisiana Tech and Southern Miss at Joe Aillet Stadium is scheduled to start at 5:00 PM ET.

• Who: Southern Miss vs. Louisiana Tech
• Date: Saturday, November 14, 2026
• Time: 5:00 PM ET/2:00 PM PT
• Venue: Joe Aillet Stadium

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Conclusion

We predict Louisiana Tech, with an 89.6% win probability, will likely beat Southern Miss in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.