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Read Article Diamondbacks vs. Rockies prediction: Why Arizona is favored to win Tuesday's MLB matchup [9/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Dimers' simulation model projects a 63.1% win probability for the Diamondbacks at Coors Field.
MLB action continues on Tuesday at 8:40 PM ET as the Arizona Diamondbacks square off with the Colorado Rockies at Coors Field.
Kyle Freeland (4-10, 6.38 ERA) will start for the Rockies, up against Michael Soroka (8-5, 3.45 ERA) for the Diamondbacks.
Dimers' proven MLB model projects the Diamondbacks as the most likely winner in this Diamondbacks vs. Rockies prediction.
This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.
Diamondbacks vs. Rockies prediction and odds
Using trusted machine learning and data, we have re-simulated the outcome of Tuesday's MLB game between the Diamondbacks and Rockies, forming part of our MLB predictions coverage.
Our independent predictive model gives the Diamondbacks a 63.1% chance of beating the Rockies. According to our model, the Diamondbacks (-1.5) have a 53.4% chance of covering the run line, while the over/under total of 10.5 runs has a 61.2% chance of going over.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Diamondbacks -1.5 (-113) / Rockies +1.5 (+113)
- Moneyline: Diamondbacks -167, Rockies +163
- Total: Over/Under 10.5 (-115/+113)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Diamondbacks -1.5 @ 53¢ via Novig
- Moneyline: Diamondbacks @ 63¢ via Novig
- Total: Over 10.5 @ 53¢ via Novig
According to our best MLB bets, the top play to make on this game is Over 10.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Tuesday's MLB matchup between the Rockies and Diamondbacks at Coors Field is scheduled to start at 8:40 PM ET.
- Who: Arizona Diamondbacks vs. Colorado Rockies
- Date: Tuesday, September 22, 2026
- Time: 8:40 PM ET/5:40PM PT
- Venue: Coors Field
Conclusion
We predict the Diamondbacks, with a 63.1% win probability, will likely beat the Rockies in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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