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Read Article Cubs vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [7/28/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs St. Louis Cardinals predictions for MLB Tuesday.
The St. Louis Cardinals will face the Chicago Cubs, in what is expected to be a close MLB game, at Busch Stadium on Tuesday, beginning at 7:45 PM ET.
The Cardinals will start Michael McGreevy (4-8, 3.07 ERA), while the Cubs are going with Colin Rea (7-7, 4.86 ERA).
Dimers' proven MLB model gives the Cardinals a slight edge with a 50.9% win probability over the Cubs.
This article offers a closer look at Tuesday's Cubs vs. Cardinals matchup, including best bets and picks.
Cubs vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the outcome of Tuesday's MLB matchup between the Cubs and Cardinals, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Cardinals a 50.9% chance of defeating the Cubs.
According to our model, the Cardinals (+1.5) have a 62.4% chance of covering the run line, while the 8.5-run over/under has a 53.9% chance of going over,.
Cubs vs. Cardinals odds [7/28/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Cardinals |
|---|---|---|
| Run Line | -1.5 (+160) | +1.5 (-163) |
| Moneyline | +100 | -102 |
| Total | o8.5 (-108) | u8.5 (+106) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Cardinals picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -163 |
| Moneyline | Cardinals | -102 |
| Total | Over 8.5 | -108 |
According to our best MLB bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Cardinals game-day updates and essential details
Tuesday's MLB matchup between the Cardinals and Cubs at Busch Stadium is scheduled to start at 7:45 PM ET.
- Who: Chicago Cubs vs. St. Louis Cardinals
- Date: Tuesday, July 28, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 50.9% win probability, will likely beat the Cubs in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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