Cardinals vs. Yankees prediction: Yankees favored to win Wednesday's MLB matchup [8/5/2026]
Get St. Louis Cardinals vs New York Yankees predictions for MLB Wednesday.
The New York Yankees will face the St. Louis Cardinals in MLB action at Yankee Stadium on Wednesday, starting at 7:05 PM ET.
Will Warren (8-5, 4.14 ERA) will be on the bump for the Yankees, while the Cardinals will counter with Andre Pallante (11-6, 3.72 ERA).
Dimers' proven MLB model projects the Yankees as the most likely winner in this Cardinals vs. Yankees prediction.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Cardinals vs. Yankees prediction: Who will win and cover?
Our independent predictive model currently gives the Yankees a 60.4% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 56.7% chance of covering the run line, while the over/under total of 8.5 runs has a 55.8% chance of going over,.
Cardinals vs. Yankees odds [8/5/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Yankees |
|---|---|---|
| Run Line | +1.5 (-144) | -1.5 (+140) |
| Moneyline | +144 | -150 |
| Total | o8.5 (-108) | u8.5 (+108) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Yankees picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Yankees -1.5 | +140 |
| Moneyline | Yankees | -150 |
| Total | Over 8.5 | hard_rock-108 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Yankees game-day updates and essential details
Wednesday's MLB matchup between the Yankees and Cardinals at Yankee Stadium is scheduled to begin at 7:05 PM ET.
- Who: St. Louis Cardinals vs. New York Yankees
- Date: Wednesday, August 5, 2026
- Time: 7:05 PM ET/4:05PM PT
- Venue: Yankee Stadium
Conclusion
We predict the Yankees, with a 60.4% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
