Louisiana-Lafayette vs. Southern California prediction favors Southern California to win in college football Week 2 [2026]

Southern California will square off with Louisiana-Lafayette in Week 2 college football action at Los Angeles Memorial Coliseum on Saturday, commencing at 11:00 PM ET.

Dimers' proven college football model projects Southern California as the most likely winner in this Louisiana-Lafayette vs. Southern California prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Louisiana-Lafayette vs. Southern California prediction and odds

Using innovative machine learning and statistical analysis, we have re-simulated the result of Louisiana-Lafayette vs. Southern California, forming part of our college football predictions coverage.

Our independent predictive model currently gives Southern California a 98.7% chance of beating Louisiana-Lafayette. Our predicted final score has Southern California winning 44-13. According to our model, Louisiana-Lafayette (+31.5) has a 52.4% chance of covering the spread, while the over/under total of 59.5 points has a 54.9% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Louisiana-Lafayette +31.5 (-109) / Southern California -31.5 (+100)
• Moneyline: Louisiana-Lafayette +3000, Southern California -6502
• Total: Over/Under 59.5 (-105/-114)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Louisiana-Lafayette +31.5 @ -109 via BetRivers
• Moneyline: Southern California @ -6502 via DraftKings
• Total: Under 59.5 @ -114 via BetRivers

According to our college football best bets, the top play to make on this game is Under 59.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southern California and Louisiana-Lafayette at Los Angeles Memorial Coliseum is scheduled to start at 11:00 PM ET.

• Who: Louisiana-Lafayette vs. Southern California
• Date: Saturday, September 12, 2026
• Time: 11:00 PM ET/8:00PM PT
• Venue: Los Angeles Memorial Coliseum

College football Week 2 promos

Make the most of Dimers' Louisiana-Lafayette vs. Southern California predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict Southern California, with a 98.7% win probability, will likely beat Louisiana-Lafayette in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.