Arizona Cardinals vs. Los Angeles Chargers: Experts release early Week 1 preview [2026]

The Arizona Cardinals and Los Angeles Chargers will meet in Week 1 of the NFL season at SoFi Stadium on Sunday, September 13, 2026, starting at 4:25 PM ET.

Early simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cardinals vs. Chargers predictions page.

Arizona vs. LA Chargers early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cardinals vs. Chargers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cardinals 22.7%, Chargers 77.3%
• Predicted final score: Cardinals 18-27 Chargers
• Spread: Cardinals (+9.5) 50.4%, Chargers (-9.5) 49.6%
• Total points (47): Over 47.3%, Under 52.7%

As of September 7, 2026, these Cardinals-Chargers figures and predictions reflect the latest data and insights available.

Cardinals vs. Chargers Week 1 details

Sunday's game between the Chargers and Cardinals at SoFi Stadium is scheduled for September 13, 2026.

• Who: Arizona Cardinals vs. Los Angeles Chargers
• Date: Sunday, September 13, 2026
• Time: 4:25 PM ET/1:25PM PT
• Venue: SoFi Stadium

Cardinals vs. Chargers opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Cardinals +9.5 (-102), Chargers -9.5 (-111)
• Moneyline: Cardinals +426, Chargers -456
• Total: Over/Under 47 (-112/-105)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 1 highlight the top candidates to score a TD in Cardinals-Chargers in Week 1:

Arizona Cardinals

• Jeremiyah Love: 35.0% probability
• Trey McBride: 30.2% probability
• Tyler Allgeier: 28.3% probability

Los Angeles Chargers

• Omarion Hampton: 52.1% probability
• Quentin Johnston: 36.4% probability
• Ladd McConkey: 36.0% probability

Cardinals vs Chargers player props

Jeremiyah Love is projected to lead rushing for the Cardinals, while Omarion Hampton is expected to pace the Chargers on the ground.

In the receiving game, our projections favor Arizona's Trey McBride and the LA Chargers' Ladd McConkey as the likely leaders for each team.

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Conclusion

We predict the Chargers, with a 77.3% win probability, will likely beat the Cardinals in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Chargers matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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