Cardinals vs. Giants prediction favors Arizona to win in NFL Week 4 [2026]

Since our Cardinals-Giants predictions earlier in the week, we have re-simulated the outcome of Sunday's NFL game between the Cardinals and Giants, forming part of our NFL predictions coverage.

Our leading predictive model currently gives the Cardinals a 56.7% chance of defeating the Giants in Week 4 of the NFL season. Our predicted final score has the Cardinals winning 23-21.

Key factors favoring the Cardinals:

• New York Giants Offense
• New York Giants Defense
• Arizona Cardinals QB Matchup

According to our model, the Giants (+2.5) have a 53.9% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 4 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: Cardinals -2.5 (+100) / Giants +2.5 (-104)
• Moneyline: Cardinals -127, Giants +125
• Total: Over/Under 44.5 (+106/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Giants +2.5 @ 51¢ via Novig
• Moneyline: Cardinals @ 56¢ via Novig
• Total: Over 44.5 @ 49¢ via Novig

According to our NFL best bets, the top play to make on this game is Giants +2.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Cardinals vs. Giants TD scorers

Who will score a touchdown in Cardinals vs. Giants?

According to our list of touchdown scorer predictions for today, Jeremiyah Love is most likely to score an anytime touchdown in Cardinals vs. Giants.

Our projections give Love a 51.5% chance of scoring a TD at MetLife Stadium, while the running back is a 14.4% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Arizona Cardinals

• Jeremiyah Love (RB): 51.5% probability
• Trey McBride (TE): 40.2%
• Michael Wilson (WR): 35.6%
• Tyler Allgeier (RB): 21.9%
• Marvin Harrison (WR): 17.5%

New York Giants

• Cam Skattebo (RB): 48.6% prob.
• Malik Nabers (WR): 30.9%
• Isaiah Likely (TE): 29.3%
• Najee Harris (RB): 17.7%
• Malachi Fields (WR): 17.2%

First touchdown scorer predictions

Arizona Cardinals

• Jeremiyah Love (RB): 14.4% prob.
• Trey McBride (TE): 10.2%
• Michael Wilson (WR): 8.8%
• Tyler Allgeier (RB): 4.9%
• Marvin Harrison (WR): 3.8%

New York Giants

• Cam Skattebo (RB): 12.1% prob.
• Malik Nabers (WR): 6.7%
• Isaiah Likely (TE): 6.3%
• Najee Harris (RB): 3.5%
• Malachi Fields (WR): 3.4%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Giants. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 4 games.

Quarterbacks

Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected for 239 passing yards, while the Giants' Jameis Winston is expected to throw for 217 yards.

Cardinals rushing

• Jeremiyah Love: 67 yds
• Tyler Allgeier: 24 yds
• Jacoby Brissett: 12 yds

Giants rushing

• Cam Skattebo: 73 yds
• Najee Harris: 28 yds
• Jameis Winston: 12 yds

Cardinals receiving

• Trey McBride: 65 yds
• Michael Wilson: 63 yds
• Marvin Harrison: 39 yds
• Kendrick Bourne: 27 yds
• Jeremiyah Love: 21 yds

Giants receiving

• Malik Nabers: 61 yds
• Isaiah Likely: 44 yds
• Malachi Fields: 30 yds
• Darnell Mooney: 26 yds
• Cam Skattebo: 21 yds

Game info & kickoff details

The NFL Week 4 action between the Giants and Cardinals at MetLife Stadium is scheduled to start at 1:00 PM ET.

• Who: Arizona Cardinals vs. New York Giants
• Date: Sunday, October 4, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: MetLife Stadium

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Conclusion

We predict the Cardinals, with a 56.7% win probability, will likely beat the Giants in Week 4 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.