Sep 21, 2026
Los Angeles Rams vs. Denver Broncos: Experts release early Week 3 predictions [2026]
Read Article Houston Texans vs. Indianapolis Colts: Experts release early Week 3 predictions [2026]
Updated: | First published:
Add Dimers on Google 
Written by Dave Garofolo, Content Producer
Get early predictions for the upcoming Texans vs Colts NFL game.
The Houston Texans and Indianapolis Colts will meet in Week 3 of the NFL season at Lucas Oil Stadium on Sunday, September 27, 2026, starting at 1:00 PM ET.
Initial simulations from Dimers' trusted NFL model favor the Texans as the most likely winner of this AFC South rivalry matchup.
For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Texans vs. Colts predictions page.
Houston vs. Indianapolis early predictions
Leveraging trusted machine learning and analysis, we have simulated the Texans vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:
- Straight up win probabilities: Texans 56.8%, Colts 43.2%
- Predicted final score: Texans 23-22 Colts
- Spread: Texans (-2.5) 46.1%, Colts (+2.5) 53.9%
- Total points (44.5): Over 54.5%, Under 45.5%
As of September 21, 2026, these Texans-Colts numbers and predictions reflect the latest data and insights available.
Texans vs. Colts Week 3 details
Sunday's game between the Colts and Texans at Lucas Oil Stadium is scheduled for September 27, 2026.
- Who: Houston Texans vs. Indianapolis Colts
- Date: Sunday, September 27, 2026
- Time: 1:00 PM ET/10:00AM PT
- Venue: Lucas Oil Stadium
Texans vs. Colts opening odds
We've researched the best betting odds across America for this Week 3 game, which are listed here:
- Spread: Texans -2.5 (-108), Colts +2.5 (+106)
- Moneyline: Texans -130, Colts +125
- Total: Over/Under 44.5 (-113/-108)
Odds may continue to move—track live changes via our NFL odds page.
NFL Week 3 promo
Make the most of Dimers' Texans vs. Colts predictions by exploring the below DraftKings Sportsbook offer:
Conclusion
We predict the Texans, with a 56.8% win probability, will likely beat the Colts in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.
Enhanced by AI and automation, this article delivers quick, accurate insights on the Texans vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee.
More on NFL
Stay up-to-date with the latest NFL news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division. &&&&&& AppContent:
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure
