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Read Article Dolphins vs. 49ers prediction favors San Francisco to win in NFL Week 2 [2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Dimers' simulation model projects an 86.5% win probability for the 49ers at Levi's Stadium.
The San Francisco 49ers and Miami Dolphins will lock horns in Week 2 of the NFL season at Levi's Stadium on Sunday, with kickoff at 4:25 PM ET.
Dimers' advanced NFL model projects the 49ers as the most likely winner in this Dolphins vs. 49ers prediction.
This article offers further insights into Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.
Dolphins vs. Niners prediction and odds
Since our Dolphins-49ers predictions earlier in the week, we have re-simulated the result of Sunday's NFL matchup between the Dolphins and 49ers, forming part of our NFL predictions coverage.
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Our leading predictive model gives the 49ers an 86.5% chance of beating the Dolphins in Week 2 of the NFL season. Our predicted final score has the 49ers winning 28-15.
Key factors favoring the 49ers:
- San Francisco 49ers Offensive Efficiency
- San Francisco 49ers Power Rankings
- San Francisco 49ers QB Change / Form
According to our model, the 49ers (-12.5) have a 51.3% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.
Latest betting odds
We have sourced the best NFL odds in America for this game, which are listed here:
- Spread: Dolphins +12.5 (-104) / 49ers -12.5 (+100)
- Moneyline: Dolphins +809, 49ers -869
- Total: Over/Under 44.5 (-108/+104)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Spread: 49ers -12.5 @ 50¢ via Polymarket
- Moneyline: Dolphins @ 11¢ via Novig
- Total: Under 44.5 @ 49¢ via Novig
According to our best NFL bets, the top play to make on this game is Dolphins to win.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Dolphins vs. 49ers TD scorers
Who will score a touchdown in Dolphins vs. 49ers?
According to our list of touchdown scorer predictions for Week 2, Christian McCaffrey is most likely to score an anytime touchdown in Dolphins vs. 49ers.
Our projections give McCaffrey a 60.4% chance of scoring a TD at Levi's Stadium, while the running back is a 17.4% chance of registering the first touchdown the game.
Anytime touchdown scorer predictions
Miami Dolphins
- De'Von Achane (RB): 43.2% probability
- Malik Willis (QB): 25.1%
- Caleb Douglas (WR): 20.3%
- Malik Washington (WR): 19.9%
- Chris Bell (WR): 14.9%
San Francisco 49ers
- Christian McCaffrey (RB): 60.4% prob.
- Mike Evans (WR): 38.9%
- George Kittle (TE): 31.9%
- Deebo Samuel (WR): 28.4%
- Kaelon Black (RB): 25.1%
First touchdown scorer predictions
Miami Dolphins
- De'Von Achane (RB): 10.1% prob.
- Malik Willis (QB): 5.2%
- Caleb Douglas (WR): 4.0%
- Malik Washington (WR): 4.0%
- Chris Bell (WR): 2.9%
San Francisco 49ers
- Christian McCaffrey (RB): 17.4% prob.
- Mike Evans (WR): 9.2%
- George Kittle (TE): 7.2%
- Deebo Samuel (WR): 6.3%
- Kaelon Black (RB): 5.4%
Top player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Dolphins and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.
Quarterbacks
Of the starting quarterbacks, the Dolphins' Malik Willis is projected for 193 passing yards. The 49ers' Brock Purdy is expected to throw for 233 yards.
Dolphins rushing
- De'Von Achane: 64 yds
- Malik Willis: 44 yds
- Jaylen Wright: 10 yds
49ers rushing
- Christian McCaffrey: 64 yds
- Kaelon Black: 41 yds
- Brock Purdy: 16 yds
Dolphins receiving
- Caleb Douglas: 43 yds
- Malik Washington: 40 yds
- De'Von Achane: 29 yds
- Chris Bell: 26 yds
- Greg Dulcich: 25 yds
49ers receiving
- Mike Evans: 55 yds
- George Kittle: 43 yds
- Deebo Samuel: 41 yds
- Christian McCaffrey: 40 yds
- Demarcus Robinson: 32 yds
Game info & kickoff details
The NFL Week 2 game between the 49ers and Dolphins at Levi's Stadium is scheduled to begin at 4:25 PM ET.
- Who: Miami Dolphins vs. San Francisco 49ers
- Date: Sunday, September 20, 2026
- Time: 4:25 PM ET/1:25PM PT
- Venue: Levi's Stadium
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Conclusion
We predict the 49ers, with an 86.5% win probability, will likely beat the Dolphins in Week 2 of the NFL season.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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