Giants vs. Rams prediction favors Rams to win ‘MNF’ Week 2 [2026]

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Written by Jason Bevilacqua

Dimers' simulation model projects a 74.1% win probability for the Rams at SoFi Stadium.

The New York Giants take on the Los Angeles Rams in NFL action.
New York Giants vs. Los Angeles Rams NFL prediction for Monday, September 21, 2026.

The Los Angeles Rams and New York Giants will meet in Week 2 of the NFL season at SoFi Stadium on Monday, with kickoff at 8:15 PM ET.

Dimers' proven NFL model projects the Rams as the most likely winner in this Giants vs. Rams prediction.

This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Giants vs. Rams prediction and odds

Since our Giants-Rams predictions earlier in the week, we have re-simulated the outcome of Monday's NFL game between the Giants and Rams, forming part of our NFL predictions coverage.

Our leading predictive model currently gives the Rams a 74.1% chance of beating the Giants in Week 2 of the NFL season. Our predicted final score has the Rams winning 27-19.

Key factors favoring the Rams:

  • Los Angeles Rams Offensive Efficiency
  • Los Angeles Rams Power Rankings
  • Los Angeles Rams QB Match-up Differential

According to our model, the Rams (-6.5) have a 56.5% chance of covering the spread, while the over/under total of 47.5 points has a 51.2% chance of staying under.

The main contributing factors to the under being more likely are:

  • New York Giants Pace
  • Los Angeles Rams Form
 

To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

  • Spread: Giants +6.5 (+113) / Rams -6.5 (-108)
  • Moneyline: Giants +285, Rams -257
  • Total: Over/Under 47.5 (+102/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

  • Spread: Rams -6.5 @ -108 via BetMGM
  • Moneyline: Rams @ 72¢ via Novig
  • Total: Under 47.5 @ 50¢ via Polymarket

According to our best NFL bets, the top play to make on this game is Rams -6.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Giants vs. Rams TD scorers

Who will score a touchdown in Giants vs. Rams?

According to our list of touchdown scorer predictions for MNF, Kyren Williams is most likely to score an anytime touchdown in Giants vs. Rams.

Our projections give Williams a 57.1% chance of scoring a TD at SoFi Stadium, while the running back is a 14.7% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

New York Giants

  • Cam Skattebo (RB): 44.4% probability
  • Malik Nabers (WR): 31.2%
  • Jaxson Dart (QB): 27.3%
  • Isaiah Likely (TE): 27.2%
  • Malachi Fields (WR): 16.3%

Los Angeles Rams

  • Kyren Williams (RB): 57.1% prob.
  • Davante Adams (WR): 43.4%
  • Blake Corum (RB): 34.5%
  • Colby Parkinson (TE): 25.6%
  • Terrance Ferguson (TE): 22.5%

First touchdown scorer predictions

New York Giants

  • Cam Skattebo (RB): 9.8% prob.
  • Malik Nabers (WR): 6.3%
  • Jaxson Dart (QB): 5.3%
  • Isaiah Likely (TE): 5.3%
  • Malachi Fields (WR): 3.0%

Los Angeles Rams

  • Kyren Williams (RB): 14.7% prob.
  • Davante Adams (WR): 9.9%
  • Blake Corum (RB): 7.4%
  • Colby Parkinson (TE): 5.2%
  • Terrance Ferguson (TE): 4.4%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Giants and Rams. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.

Quarterbacks

Of the starting quarterbacks, the Giants' Jaxson Dart is projected for 215 passing yards, while the Rams' Matthew Stafford is expected to throw for 251 yards.

Giants rushing

  • Cam Skattebo: 60 yds
  • Jaxson Dart: 38 yds
  • Devin Singletary: 16 yds

Rams rushing

  • Kyren Williams: 68 yds
  • Blake Corum: 53 yds
  • Ronnie Rivers: 3 yds

Giants receiving

  • Malik Nabers: 66 yds
  • Isaiah Likely: 47 yds
  • Malachi Fields: 32 yds
  • Darnell Mooney: 25 yds
  • Cam Skattebo: 14 yds

Rams receiving

  • Davante Adams: 69 yds
  • Terrance Ferguson: 36 yds
  • Colby Parkinson: 35 yds
  • Konata Mumpfield: 23 yds
  • Xavier Smith: 23 yds

Game info & kickoff details

The NFL Week 2 game between the Rams and Giants at SoFi Stadium is scheduled to start at 8:15 PM ET.

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Conclusion

We predict the Rams, with a 74.1% win probability, will likely beat the Giants in Week 2 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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