NFL best bets today: Week 2 picks include Jaguars vs. Broncos play [9/20/2026]

Jaguars +2.5 (+113)

• Edge: 6.9%
• Probability: 53.9%
• Matchup: Jaguars vs. Broncos (4:05PM ET)

Our model has identified value on Jaguars +2.5 at 47¢ odds. A 53.9% probability produces an edge of 6.9%, making this the strongest play for today's NFL slate.

Bengals +2.5 (+108)

• Edge: 6.8%
• Probability: 54.9%
• Matchup: Bengals vs. Texans (1:00PM ET)

Bengals +2.5 carries a 6.8% edge and a probability of 54.9% at 48¢ odds, according to our model.

Bengals vs. Texans Over 45.5 points (-104)

• Edge: 6.7%
• Probability: 57.7%
• Matchup: Bengals vs. Texans (1:00PM ET)

Bengals vs. Texans Over 45.5 points at 51¢ odds shows a 6.7% edge, supported by a 57.7% probability in simulations.

Cardinals +3.5 (+102)

• Edge: 5.7%
• Probability: 55.2%
• Matchup: Seahawks vs. Cardinals (4:25PM ET)

A 5.7% edge and 55.2% probability makes Cardinals +3.5 vs. Seahawks a value play in the Seahawks vs. Cardinals matchup, per our model.

Bengals ML (+144)

• Edge: 3.9%
• Probability: 44.9%
• Matchup: Bengals vs. Texans (1:00PM ET)

Bengals ML at 41¢ presents a 3.9% edge, with simulations resulting in a probability of 44.9%.

Cardinals ML (+186)

• Edge: 3.8%
• Probability: 38.8%
• Matchup: Seahawks vs. Cardinals (4:25PM ET)

Our model finds value on Cardinals to win at 35¢, supported by an edge of 3.8%.

Browns ML (+376)

• Edge: 3.3%
• Probability: 25.3%
• Matchup: Browns vs. Buccaneers (1:00PM ET)

Our model has uncovered value on Browns-Buccaneers to finish as a tie after 90 minutes at 21¢. A 25.3% probability produces a 3.3% edge, making this a strong play for today's NFL action.

Bears -3.5 (-108)

• Edge: 3.1%
• Probability: 55.1%
• Matchup: Vikings vs. Bears (1:00PM ET)

A 3.1% edge on a 55.1% probability makes Bears -3.5 at 52¢a solid value play in today's Vikings vs. Bears matchup.

Eagles -7.5 (+113)

• Edge: 3.1%
• Probability: 50%
• Matchup: Eagles vs. Titans (1:00PM ET)

Our model projects value on Eagles -7.5 at 47¢. A 50% probability produces a 3.1% edge, making Eagles the favorable side in today's matchup.

Vikings vs. Bears Over 48.5 points (+104)

• Edge: 2.9%
• Probability: 51.9%
• Matchup: Vikings vs. Bears (1:00PM ET)

Rounding out our top 10 bets, Vikings vs. Bears Over 48.5 points at 49¢ shows a 51.9% probability and a 2.9% edge.

NFL best bets summary: Sunday, 9/20/2026

As of 5:17AM ET, here are our top NFL bets by edge recommended by our model:

List of upcoming NFL games to bet on [9/20/2026]

• Eagles vs. Titans (1:00PM ET, Sunday)
• Steelers vs. Patriots (1:00PM ET, Sunday)
• Vikings vs. Bears (1:00PM ET, Sunday)
• Panthers vs. Falcons (1:00PM ET, Sunday)
• Packers vs. Jets (1:00PM ET, Sunday)
• Saints vs. Ravens (1:00PM ET, Sunday)
• Bengals vs. Texans (1:00PM ET, Sunday)
• Browns vs. Buccaneers (1:00PM ET, Sunday)
• Jaguars vs. Broncos (4:05PM ET, Sunday)
• Raiders vs. Chargers (4:05PM ET, Sunday)
• Seahawks vs. Cardinals (4:25PM ET, Sunday)
• Dolphins vs. 49ers (4:25PM ET, Sunday)
• Commanders vs. Cowboys (4:25PM ET, Sunday)
• Colts vs. Chiefs (8:20PM ET, Sunday)

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Conclusion

Our NFL best bets are locked and loaded for September 20, 2026, featuring plays such as Jaguars +2.5 vs. Broncos and Bengals +2.5. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.