Eagles vs. Titans prediction: Why Philadelphia is favored to win in NFL Week 2 [2026]

Since our Eagles-Titans predictions earlier in the week, we have re-simulated the result of Sunday's NFL matchup between the Eagles and Titans, forming part of our NFL predictions coverage.

Our leading predictive model gives the Eagles a 74.2% chance of defeating the Titans in Week 2 of the NFL season. Our predicted final score has the Eagles winning 23-16.

Key factors favoring the Eagles:

• Tennessee Titans Offensive Efficiency
• Philadelphia Eagles Power Rankings
• Philadelphia Eagles QB Match-up Differential

According to our model, the oddsmakers have got it right, and the Eagles and Titans each have a 50% chance of covering the spread, while the 39.5-point over/under also has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: Eagles -7.5 (+113) / Titans +7.5 (-115)
• Moneyline: Eagles -317, Titans +300
• Total: Over/Under 39.5 (-102/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Eagles -7.5 @ 47¢ via Novig
• Moneyline: Titans @ 25¢ via Novig
• Total: Under 39.5 @ 50¢ via Novig

According to our NFL best bets, the top play to make on this game is Eagles -7.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Eagles vs. Titans TD scorers

Who will score a touchdown in Eagles vs. Titans?

According to our model, Saquon Barkley is most likely to score an anytime TD in Eagles vs. Titans.

Our projections give Barkley a 50.1% chance of scoring a TD at Nissan Stadium, while the running back is a 12.6% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Philadelphia Eagles

• Saquon Barkley (RB): 50.1% probability
• Jalen Hurts (QB): 40.3%
• DeVonta Smith (WR): 32.1%
• Dallas Goedert (TE): 30.5%
• Dontayvion Wicks (WR): 23.0%

Tennessee Titans

• Tony Pollard (RB): 27.9% prob.
• Tyjae Spears (RB): 20.7%
• Carnell Tate (WR): 19.5%
• Wan'Dale Robinson (WR): 15.6%
• Gunnar Helm (TE): 15.0%

First touchdown scorer predictions

Philadelphia Eagles

• Saquon Barkley (RB): 12.6% prob.
• Jalen Hurts (QB): 9.4%
• DeVonta Smith (WR): 7.0%
• Dallas Goedert (TE): 6.6%
• Dontayvion Wicks (WR): 4.7%

Tennessee Titans

• Tony Pollard (RB): 7.8% prob.
• Tyjae Spears (RB): 5.5%
• Carnell Tate (WR): 5.2%
• Wan'Dale Robinson (WR): 4.0%
• Gunnar Helm (TE): 3.9%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Eagles and Titans. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.

Quarterbacks

Of the starting quarterbacks, the Eagles' Jalen Hurts is projected for 209 passing yards, while the Titans' Cam Ward is expected to throw for 192 yards.

Eagles rushing

• Saquon Barkley: 76 yds
• Jalen Hurts: 32 yds
• Tank Bigsby: 15 yds

Titans rushing

• Tony Pollard: 43 yds
• Tyjae Spears: 23 yds
• Cam Ward: 13 yds

Eagles receiving

• DeVonta Smith: 64 yds
• Dallas Goedert: 40 yds
• Dontayvion Wicks: 36 yds
• Makai Lemon: 32 yds
• Saquon Barkley: 15 yds

Titans receiving

• Carnell Tate: 46 yds
• Wan'Dale Robinson: 43 yds
• Gunnar Helm: 27 yds
• Calvin Ridley: 24 yds
• Tyjae Spears: 18 yds

Game info & kickoff details

The NFL Week 2 matchup between the Titans and Eagles at Nissan Stadium is scheduled to start at 1:00 PM ET.

• Who: Philadelphia Eagles vs. Tennessee Titans
• Date: Sunday, September 20, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Nissan Stadium

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Conclusion

We predict the Eagles, with a 74.2% win probability, will likely beat the Titans in Week 2 of the NFL season.

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This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.