Seattle Seahawks vs. Arizona Cardinals: Experts release early Week 2 predictions [2026]

The Seattle Seahawks and Arizona Cardinals will meet in Week 2 of the NFL season at State Farm Stadium on Sunday, September 20, 2026, starting at 4:25 PM ET.

Initial simulations from Dimers' trusted NFL model favor the Seahawks as the most likely winner of this NFC West rivalry clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Seahawks vs. Cardinals predictions page.

Seattle vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Seahawks vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Seahawks 66.6%, Cardinals 33.4%
• Predicted final score: Seahawks 23-18 Cardinals
• Spread: Seahawks (-4.5) 51.6%, Cardinals (+4.5) 48.4%
• Total points (40.5): Over 54.7%, Under 45.3%

As of September 14, 2026, these Seahawks-Cardinals numbers and predictions reflect the latest data and insights available.

Seahawks vs. Cardinals Week 2 details

Sunday's matchup between the Cardinals and Seahawks at State Farm Stadium is scheduled for September 20, 2026.

• Who: Seattle Seahawks vs. Arizona Cardinals
• Date: Sunday, September 20, 2026
• Time: 4:25 PM ET/1:25PM PT
• Venue: State Farm Stadium

Seahawks vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Seahawks -4.5 (+100), Cardinals +4.5 (-108)
• Moneyline: Seahawks -213, Cardinals +208
• Total: Over/Under 40.5 (+100/-103)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Seahawks, with a 66.6% win probability, will likely beat the Cardinals in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Seahawks vs. Cardinals game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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