Seahawks vs. Cardinals prediction: Why Seattle is favored to win in NFL Week 2 [2026]

Since our Seahawks-Cardinals predictions earlier in the week, we have re-simulated the result of Sunday's NFL matchup between the Seahawks and Cardinals, forming part of our NFL predictions coverage.

Our leading predictive model gives the Seahawks a 61.2% chance of defeating the Cardinals in Week 2 of the NFL season. Our predicted final score has the Seahawks winning 22-19.

Key factors favoring the Seahawks:

• Seattle Seahawks Power Rankings
• Arizona Cardinals QB Change / Form
• Seattle Seahawks Defensive Efficiency

According to our model, the Cardinals (+3.5) have a 55.2% chance of covering the spread, while the 41.5-point over/under has a 50.6% chance of going over.

The main contributing factors to the over being more likely are:

• Weather / Conditions
• Seattle Seahawks Form

To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: Seahawks -3.5 (-104) / Cardinals +3.5 (+102)
• Moneyline: Seahawks -190, Cardinals +186
• Total: Over/Under 41.5 (+104/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Cardinals +3.5 @ 50¢ via Novig
• Moneyline: Cardinals @ 35¢ via Novig
• Total: Over 41.5 @ 49¢ via Polymarket

According to our NFL best bets, the top play to make on this game is Cardinals +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Seahawks vs. Cardinals TD scorers

Who will score a touchdown in Seahawks vs. Cardinals?

According to our list of touchdown scorer predictions for today, Jaxon Smith-Njigba is most likely to score an anytime touchdown in Seahawks vs. Cardinals.

Our projections give Smith-Njigba a 38.0% chance of scoring a TD at State Farm Stadium, while the running back is a 9.6% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Seattle Seahawks

• Jaxon Smith-Njigba (WR): 38.0% probability
• Jadarian Price (RB): 35.4%
• George Holani (RB): 29.4%
• AJ Barner (TE): 22.0%
• Rashid Shaheed (WR): 18.6%

Arizona Cardinals

• Jeremiyah Love (RB): 33.3% prob.
• Trey McBride (TE): 28.2%
• Tyler Allgeier (RB): 25.8%
• Marvin Harrison (WR): 20.4%
• Michael Wilson (WR): 19.8%

First touchdown scorer predictions

Seattle Seahawks

• Jaxon Smith-Njigba (WR): 9.6% prob.
• Jadarian Price (RB): 8.8%
• George Holani (RB): 7.0%
• AJ Barner (TE): 5.0%
• Rashid Shaheed (WR): 4.1%

Arizona Cardinals

• Jeremiyah Love (RB): 9.7% prob.
• Trey McBride (TE): 7.9%
• Tyler Allgeier (RB): 7.2%
• Marvin Harrison (WR): 5.5%
• Michael Wilson (WR): 5.3%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Seahawks and Cardinals. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.

Quarterbacks

Of the starting quarterbacks, the Seahawks' Drew Lock is projected for 205 passing yards. The Cardinals' Jacoby Brissett is expected to throw for 224 yards.

Seahawks rushing

• Jadarian Price: 66 yds
• George Holani: 31 yds
• Drew Lock: 13 yds

Cardinals rushing

• Jeremiyah Love: 41 yds
• Tyler Allgeier: 36 yds
• Jacoby Brissett: 13 yds

Seahawks receiving

• Jaxon Smith-Njigba: 84 yds
• Rashid Shaheed: 31 yds
• Cooper Kupp: 29 yds
• AJ Barner: 27 yds
• Elijah Arroyo: 15 yds

Cardinals receiving

• Trey McBride: 61 yds
• Michael Wilson: 44 yds
• Marvin Harrison: 41 yds
• Kendrick Bourne: 31 yds
• Jeremiyah Love: 20 yds

Game info & kickoff details

The NFL Week 2 action between the Cardinals and Seahawks at State Farm Stadium is scheduled to commence at 4:25 PM ET.

• Who: Seattle Seahawks vs. Arizona Cardinals
• Date: Sunday, September 20, 2026
• Time: 4:25 PM ET/1:25PM PT
• Venue: State Farm Stadium

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Conclusion

We predict the Seahawks, with a 61.2% win probability, will likely beat the Cardinals in Week 2 of the NFL season.

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This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.