Newcastle Knights vs. Manly Sea Eagles prediction: Knights favored to win Saturday's NRL Round 25 matchup [8/22/2026]

The Newcastle Knights and Manly Sea Eagles are scheduled to meet in the National Rugby League (NRL) at McDonald Jones Stadium on Saturday, starting at 1:00 AM ET.

Dimers' proven NRL model projects the Knights as the most likely winner in this Sea Eagles vs. Knights prediction.

This article offers further insights into Saturday's matchup, including best bets and picks.

Knights vs. Sea Eagles prediction: Who will win Round 25 game?

Using trusted machine learning and data, we have simulated the outcome of Saturday's NRL matchup between the Sea Eagles and Knights, forming part of our NRL predictions coverage.

Our famous predictive model currently gives the Knights a 70.3% chance of defeating the Sea Eagles.

According to our model, the Knights (-7.5) have a 55.2% chance of covering the spread, while the over/under total of 50.5 points has a 54.2% chance of staying under.

Manly vs. Knights odds

We have sourced the best NRL odds in America for this game, which are listed here:

• Moneyline: Sea Eagles +190, Knights -250

All odds are correct at the time of publication and are subject to change.

Sea Eagles vs. Knights picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Knights -7.5 @ -120 via DraftKings
• Moneyline: Knights @ -250 via BetRivers
• Total: Under 50.5 @ -112 via BetRivers

According to our NRL best bets, the top play to make on this game is Under 50.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Knights vs. Sea Eagles game-day updates and essential details

Saturday's Australian rugby league matchup between the Knights and Sea Eagles at McDonald Jones Stadium is scheduled to commence at 1:00 AM ET.

• Who: Manly Sea Eagles vs. Newcastle Knights
• Date: Saturday, August 22, 2026
• Time: 1:00 AM ET/10:00PM PT
• Venue: McDonald Jones Stadium

The NRL is available to bet on in the US through all major sportsbooks, with there even being games played in Vegas each season as of 2024.

Conclusion

We predict the Knights, with a 70.3% win probability, will likely beat the Sea Eagles in Saturday's NRL matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.