Colgate vs. Villanova prediction favors Villanova to win in college football Week 4 [2026]

Villanova will take on Colgate in Week 4 college football action at Villanova Stadium on Saturday, beginning at 2:30 PM ET.

Dimers' advanced college football model projects Villanova as the most likely winner in this Colgate vs. Villanova prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Colgate vs. Villanova prediction and odds

Using trusted machine learning and data, we have re-simulated the result of Colgate vs. Villanova, forming part of our college football predictions coverage.

Our leading predictive model gives Villanova a 60.0% chance of beating Colgate. Our predicted final score has Villanova winning 25-20. According to our model, Villanova (-3.5) has a 51.4% chance of covering the spread, while the 44.5-point over/under has a 54.1% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Colgate +3.5 (-109) / Villanova -3.5 (-110)
• Moneyline: Colgate +132, Villanova -147
• Total: Over/Under 44.5 (-108/-111)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Villanova -3.5 @ -110 via bet365
• Moneyline: Villanova @ -147 via DraftKings
• Total: Over 44.5 @ -108 via Caesars

According to our college football best bets, the top play to make on this game is Over 44.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Villanova and Colgate at Villanova Stadium is scheduled to commence at 2:30 PM ET.

• Who: Colgate vs. Villanova
• Date: Saturday, September 26, 2026
• Time: 2:30 PM ET/11:30AM PT
• Venue: Villanova Stadium

College football Week 4 promos

Make the most of Dimers' Colgate vs. Villanova predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Villanova, with a 60.0% win probability, will likely beat Colgate in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.