Holy Cross vs. Lafayette prediction favors Lafayette to win in college football Week 4 [2026]

Lafayette and Holy Cross will meet in Week 4 college football action at Fisher Stadium on Saturday, starting at 12:30 PM ET.

Dimers' proven college football model projects Lafayette as the most likely winner in this Holy Cross vs. Lafayette prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Holy Cross vs. Lafayette prediction and odds

Using innovative machine learning and data, we have re-simulated the outcome of Holy Cross vs. Lafayette, forming part of our college football predictions coverage.

Our independent predictive model currently gives Lafayette a 62.9% chance of defeating Holy Cross. Our predicted final score has Lafayette winning 25-21. According to our model, Holy Cross (+4) has a 50.2% chance of covering the spread, while the over/under total of 46 points has a 54.7% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +4 (-113) / Lafayette -4 (-109)
• Moneyline: Holy Cross +150, Lafayette -180
• Total: Over/Under 46 (-109/-113)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Lafayette -4 @ -109 via Caesars
• Moneyline: Lafayette @ -180 via DraftKings
• Total: Over 46 @ -109 via Caesars

According to our college football best bets, the top play to make on this game is Over 46 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Lafayette and Holy Cross at Fisher Stadium is scheduled to start at 12:30 PM ET.

• Who: Holy Cross vs. Lafayette
• Date: Saturday, September 26, 2026
• Time: 12:30 PM ET/9:30AM PT
• Venue: Fisher Stadium

College football Week 4 promos

Make the most of Dimers' Holy Cross vs. Lafayette predictions by exploring the Underdog Fantasy offer below:

Conclusion

We predict Lafayette, with a 62.9% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.