Notre Dame vs. Purdue prediction: Why Notre Dame is favored to win in college football Week 4 [2026]

Purdue will take on the favored Notre Dame in Week 4 college football action at Ross-Ade Stadium on Saturday, commencing at 2:00 PM ET.

Dimers' proven college football model projects Notre Dame as the most likely winner in this Notre Dame vs. Purdue prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Notre Dame vs. Purdue prediction and odds

Using trusted machine learning and statistical analysis, we have re-simulated the outcome of Notre Dame vs. Purdue, forming part of our college football predictions coverage.

Our leading predictive model gives Notre Dame a 97.2% chance of defeating Purdue. Our predicted final score has Notre Dame winning 41-15. According to our model, Purdue (+27.5) has a 52.7% chance of covering the spread, while the 56.5-point over/under has a 51.9% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Notre Dame -27.5 (-105) / Purdue +27.5 (-110)
• Moneyline: Notre Dame -4500, Purdue +1700
• Total: Over/Under 56.5 (-114/-103)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Purdue +27.5 @ -110 via DraftKings
• Moneyline: Notre Dame @ -4500 via DraftKings
• Total: Over 56.5 @ -114 via FanDuel

According to our best college football bets, the top play to make on this game is Purdue +27.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Purdue and Notre Dame at Ross-Ade Stadium is scheduled to begin at 2:00 PM ET.

• Who: Notre Dame vs. Purdue
• Date: Saturday, September 26, 2026
• Time: 2:00 PM ET/11:00AM PT
• Venue: Ross-Ade Stadium

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Conclusion

We predict Notre Dame, with a 97.2% win probability, will likely beat Purdue in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.