Oregon vs. Southern California prediction favors Oregon to win in college football Week 4 [2026]

Southern California will face Oregon in Week 4 college football action at Los Angeles Memorial Coliseum on Saturday, commencing at 7:30 PM ET.

Dimers' proven college football model projects Oregon as the most likely winner in this Oregon vs. Southern California prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Oregon vs. Southern California prediction and odds

Using trusted machine learning and data analysis, we have re-simulated the result of Oregon vs. Southern California, forming part of our college football predictions coverage.

Our independent predictive model gives Oregon a 64.1% chance of defeating Southern California. Our predicted final score has Oregon winning 32-28. According to our model, Southern California (+7.5) has a 61.1% chance of covering the spread, while the over/under total of 55.5 points has a 59.8% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Oregon -7.5 (-107) / Southern California +7.5 (-118)
• Moneyline: Oregon -180, Southern California +250
• Total: Over/Under 55.5 (-116/-115)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern California +7.5 @ -118 via FanDuel
• Moneyline: Southern California @ +250 via FanDuel
• Total: Over 55.5 @ -116 via DraftKings

According to our college football best bets, the top play to make on this game is Southern California to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southern California and Oregon at Los Angeles Memorial Coliseum is scheduled to commence at 7:30 PM ET.

• Who: Oregon vs. Southern California
• Date: Saturday, September 26, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Los Angeles Memorial Coliseum

College football Week 4 promos

Make the most of Dimers' Oregon vs. Southern California predictions by exploring the Underdog Fantasy offer below:

Conclusion

We predict Oregon, with a 64.1% win probability, will likely beat Southern California in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.