Sep 29, 2026
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Read Article White Sox vs. Astros prediction: Houston favored to win Tuesday's MLB matchup [9/29/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Dimers' simulation model projects a 58.8% win probability for the Astros at Daikin Park.
The Houston Astros will face the Chicago White Sox in MLB action at Daikin Park on Tuesday, starting at 5:00 PM ET.
AJ Blubaugh (0-0, 0.00 ERA) will be the starting pitcher for the Astros, up against Hagen Smith (0-0, 0.00 ERA) for the White Sox.
Dimers' proven MLB model projects the Astros as the most likely winner in this White Sox vs. Astros prediction.
This article offers a closer look at Tuesday's matchup, including best bets and picks.
White Sox vs. Astros prediction and odds
Using trusted machine learning and data analysis, we have re-simulated the result of Tuesday's MLB game between the White Sox and Astros, forming part of our MLB predictions coverage.
Our independent predictive model gives the Astros a 58.8% chance of beating the White Sox. According to our model, the White Sox (+1.5) have a 55.6% chance of covering the run line, while the 8.5-run over/under has a 53.0% chance of going over.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: White Sox +1.5 (-167) / Astros -1.5 (+178)
- Moneyline: White Sox +113, Astros -115
- Total: Over/Under 8.5 (+104/-108)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Astros -1.5 @ 36¢ via Novig
- Moneyline: Astros @ -115 via BetMGM
- Total: Over 8.5 @ 49¢ via Novig
According to our MLB best bets, the top play to make on this game is Astros -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Tuesday's MLB action between the Astros and White Sox at Daikin Park is scheduled to commence at 5:00 PM ET.
- Who: Chicago White Sox vs. Houston Astros
- Date: Tuesday, September 29, 2026
- Time: 5:00 PM ET/2:00PM PT
- Venue: Daikin Park
Conclusion
We predict the Astros, with a 58.8% win probability, will likely beat the White Sox in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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