Sep 29, 2026
Cubs vs. Padres prediction: San Diego favored to win Tuesday's MLB matchup [9/29/2026]
Read Article MLB picks today: Tuesday's MLB best bets include Red Sox vs. Yankees play [9/29/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB picks today and best bets for Tuesday, September 29, 2026.
Today’s MLB picks for September 29, 2026 are here, with Red Sox vs. Yankees and Cubs vs. Padres among the top plays identified by our model across Tuesday’s MLB postseason play.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to uncover real betting edges. The result? Data-backed plays that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [9/29, updated 6:03PM ET]
Below, you’ll find today’s MLB best bets, ranked by edge for Tuesday, September 29, 2026.
Red Sox vs. Yankees Over 6.5 runs (+117)
- Edge: 9.6%
- Probability: 55.7%
- Matchup: Red Sox vs. Yankees (8:00PM ET)
Our model has identified value on Over 6.5 runs in Red Sox vs. Yankees at 46¢ odds. A 55.7% probability produces an edge of 9.6%, making this the strongest play for today's MLB slate.
Cubs vs. Padres Over 7.5 runs (+106)
- Edge: 3.1%
- Probability: 51.6%
- Matchup: Cubs vs. Padres (10:00PM ET)
Cubs vs. Padres over 7.5 runs carries a 3.1% edge and a probability of 51.6% at 49¢ odds, according to our model.
Yankees -1.5 (+190)
- Edge: 2.4%
- Probability: 36.9%
- Matchup: Red Sox vs. Yankees (8:00PM ET)
Yankees -1.5 vs. Red Sox at 34¢ odds shows a 2.4% edge, supported by a 36.9% probability in simulations.
MLB Playoffs best bets summary: Tuesday, 9/29/2026
As of 6:03PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Prob. |
|---|---|---|---|---|
| Red Sox vs. Yankees | Over 6.5 runs | 46¢ @ Novig | 9.6% | 55.7% |
| Cubs vs. Padres | Over 7.5 runs | 49¢ @ Novig | 3.1% | 51.6% |
| Red Sox vs. Yankees | Yankees -1.5 | 34¢ @ Novig | 2.4% | 36.9% |
List of upcoming MLB postseason games to bet on [9/29/2026]
- Red Sox vs. Yankees (8:00PM ET, Tuesday)
- Cubs vs. Padres (10:00PM ET, Tuesday)
- Phillies vs. Braves (2:00PM ET, Wednesday)
Conclusion
Our MLB best bets are locked and loaded for September 29, 2026, featuring plays such as over 6.5 runs in the Red Sox vs. Yankees matchup and over 7.5 runs in the Cubs vs. Padres matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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