St Louis City vs. Portland Timbers prediction, odds, MLS Cup first round picks [10/28/2026]

MLS Cup action continues on Wednesday at 8:30 PM ET as Portland locks horns with St Louis City in the first round at CITYPARK.

Dimers' proven MLS model projects St Louis City as the most likely winner in this St Louis City vs. Portland prediction.

This article offers a closer look at Wednesday's match, including best bets and picks.

St Louis City vs. Portland Timbers prediction and odds

Using innovative machine learning and data analysis, we have re-simulated the result of Wednesday's MLS matchup between St Louis City and Portland, forming part of our MLS predictions coverage.

Our famous predictive model currently suggests a 58.8% chance of St Louis City winning, a 21.5% chance for Portland, and a 19.7% chance of a draw. Additionally, the over/under total of 2.5 goals has a 70.1% chance of going over., according to our model.

Latest betting odds

We have researched the best MLS odds in America for this game, which are listed here:

• Moneyline: Portland +300, St Louis City -104
• Total Goals: Over/Under 2.5 (-212/+203)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet for MLS Cup first round

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: St Louis City @ -104 via Novig
• Total Goals: Over 2.5 @ -212 via Novig

According to our MLS best bets, the top play to make on this game is St Louis City to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score projections

Here are the top three most likely final scores according to our model, with a 2-1 St Louis City win being the most probable:

• St Louis City 2-1 Portland (9.3% probability)
• St Louis City 1-1 Portland (8.2%)
• St Louis City 3-1 Portland (7.1%)

Game info & kickoff details

Wednesday's MLS action between St Louis City and Portland in MLS at CITYPARK is scheduled to commence at 8:30 PM ET.

• Who: St Louis City vs. Portland Timbers
• Date: Wednesday, October 28, 2026
• Time: 8:30 PM ET/5:30 PM PT
• Venue: CITYPARK

Conclusion

According to our computer model, St Louis City has a 58.8% win probability on Wednesday, Portland has a 21.5% win probability, and there is a 19.7% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary MLS prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.